Haptoglobin genotyping of Vietnamese: Global distribution of HPdel, complete deletion allele of the HP gene

Title: Haptoglobin genotyping of Vietnamese: Global distribution of HPdel, complete deletion allele of the HP gene
Authors: Soejima, Mikiko
Agusa, Tetsuro
Iwata, Hisato
Keywords: Gene deletion;Geographic distribution;;Ancestry informative marker;Anaphylaxis
Issue Date: 2015
Publisher: ELSEVIER IRELAND LTD, ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND
Citation: ISIKNOWLEDGE
Abstract: The haptoglobin (HP) gene deletion allele (HPdel) is responsible for anhaptoglobinemia and a genetic risk factor for anaphylaxis reaction after transfusion due to production of the anti-HP antibody. The distribution of this allele has been explored by several groups including ours. Here, we studied the frequency of HPdel in addition to the distribution of common HP genotypes in 293 Vietnamese. The HPdel was encountered with the frequency of 0.020. The present result suggested that this deletion allele is restricted to East and Southeast Asians. Thus, this allele seems to be a potential ancestry informative marker for these populations. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
Description: LEGAL MEDICINE Volume: 17 Issue: 1 Pages: 14-16 Published: JAN 2015 ; TNS05817
URI: http://www.legalmedicinejournal.com/article/S1344-6223(14)00131-X/fulltext
http://repository.vnu.edu.vn/handle/VNU_123/33074
ISSN: 1344-6223
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