Haptoglobin genotyping of Vietnamese: Global distribution of HPdel, complete deletion allele of the HP gene
Title: Haptoglobin genotyping of Vietnamese: Global distribution of HPdel, complete deletion allele of the HP gene Authors: Soejima, Mikiko Agusa, Tetsuro Iwata, Hisato Keywords: Gene deletion;Geographic distribution;;Ancestry informative marker;Anaphylaxis Issue Date: 2015 Publisher: ELSEVIER IRELAND LTD, ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND Citation: ISIKNOWLEDGE Abstract: The haptoglobin (HP) gene deletion allele (HPdel) is responsible for anhaptoglobinemia and a genetic risk factor for anaphylaxis reaction after transfusion due to production of the anti-HP antibody. The distribution of this allele has been explored by several groups including ours. Here, we studied the frequency of HPdel in addition to the distribution of common HP genotypes in 293 Vietnamese. The HPdel was encountered with the frequency of 0.020. The present result suggested that this deletion allele is restricted to E...